Composes de phosphonate therapeutiques

Therapeutic phosphonate compounds

Abstract

The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.
La présente invention a trait à des agents thérapeutiques substitués de phosphore, des compositions contenant de tels agents substitués de phosphore, et des procédés thérapeutiques comprenant l'administration de tels agents substitués de phosphore, ainsi que des procédés et des intermédiaires utiles pour la préparation de tels agents.

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Patent Citations (7)

    Publication numberPublication dateAssigneeTitle
    EP-0632048-A1January 04, 1995Mitsubishi Chemical CorporationPhosphonate-nucleotide ester derivatives
    EP-0919562-A1June 02, 1999Mitsubishi Chemical CorporationPhosphonat-nukleotid-verbindungen
    WO-0164693-A1September 07, 2001Mitsubishi Pharma CorporationCompose de nucleotide de phosphonate
    WO-02057425-A2July 25, 2002Merck & Co., Inc., Isis Pharmaceuticals, Inc.Derives de nucleoside comme inhibiteurs de l'arn polymerase virale arn-dependante
    WO-0208241-A2January 31, 2002Gilead Sciences, Inc.Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
    WO-03028737-A1April 10, 2003Mitsubishi Pharma CorporationAgents antiviraux et procede in-vitro d'identification de candidats empechant la fixation de la polymerase a l'epsilon
    WO-03050129-A1June 19, 2003Eli Lilly And CompanyUse of phosphonate nucleotide analogue for treating hepatitis b virus infections

NO-Patent Citations (8)

    Title
    CHAPMAN H ET AL: "Practical synthesis, separation, and stereochemical assignment of the PMPA pro-drug GS-7340" NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS, MARCEL DEKKER, ANN HARBOR, MI, US, vol. 20, no. 4-7, 2001, pages 621-628, XP002202043 ISSN: 1525-7770
    CLERCQ DE E: "HIGHLIGHTS IN THE DEVELOPMENT OF NEW ANTIVIRAL AGENTS" MINI REVIEWS IN MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS, HILVERSUM, NL, vol. 2, no. 2, April 2002 (2002-04), pages 163-175, XP009035765 ISSN: 1389-5575
    GUMINA GIUSEPPE ET AL: "Advances in antiviral agents for hepatitis B virus" ANTIVIRAL CHEMISTRY AND CHEMOTHERAPY, vol. 12, no. Supplement 1, 2001, pages 93-117, XP009038411 ISSN: 0956-3202
    KARPENKO INNA L ET AL: "Synthesis and antiherpetic activity of acyclovir phosphonates." NUCLEOSIDES NUCLEOTIDES AND NUCLEIC ACIDS, vol. 22, no. 3, March 2003 (2003-03), pages 319-328, XP009038425 ISSN: 1525-7770
    KIM C U ET AL: "REGIOSPECIFIC AND HIGHLY STEREOSELECTIVE ELECTROPHILIC ADDITION TO FURANOID GLYCALS SYNTHESIS OF PHOSPHONATE NUCLEOTIDE ANALOGUES WITH POTENT ACTIVITY AGAINST HIV" JOURNAL OF ORGANIC CHEMISTRY, vol. 56, no. 8, 1991, pages 2642-2647, XP002301628 ISSN: 0022-3263
    ONO-NITA SUZANE KIOKO ET AL: "Novel nucleoside analogue MCC-478 (LY582563) is effective against wild-type or lamivudine-resistant hepatitis B virus" ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 46, no. 8, August 2002 (2002-08), pages 2602-2605, XP002245846 ISSN: 0066-4804
    SCHULTZ C: "Prodrugs of biologically active phosphate esters" BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 11, 2003, pages 885-898, XP002972467 ISSN: 0968-0896
    SEKIYA K ET AL: "2-Amino-6-arylthio-9-[2-(phosphonomethoxy )ethylÜpurine Bis(2,2,2-trifluoroethyl) Esters as Novel HBV-Specific Antiviral Reagents" JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 45, 6 April 2002 (2002-04-06), pages 3138-3142, XP002221469 ISSN: 0022-2623

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