REICH REUVEN (Total 48 Patents Found)

The invention provides novel methods for treating disease based upon the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers. Phosphatidylethanolamine moieties conjugated to physiologically acceptable monomers and polymers (PE conjugates) manifest an unexpectedl...
A phospholipid conjugate according to the general formula (I) or according to the general formula (II) for use in the treatment or prevention of a disorder selected from skin hypersensitivity, respiratory disease, eye disorder, and inflammatory bowel disease....
The invention provides novel methods for treating disease based upon the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers. Phosphatidylethanolamine moieties conjugated to physiologically acceptable monomers and polymers (PE conjugates) manifest an unexpectedl...
ABSTRACT OF THE INVENTION The present invention relates to a method of inhibiting tumor metastasis in an animal by administering to an animal in need of such treatment an acylaminoalkylpyridineamides represented by the formula wherein: R1 and R2 are the same or different members of the group consisting of halo,...
The present invention relates to a method of inhibiting tumor metastasis in an animal by administering to an animal in need of such treatment an acylaminoalkylpyridineamides represented by the formula wherein: R₁ and R₂ are the same or different members of the group consisting of halo, phenyl, substit...
The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active ingredient in these compositions is an alpha-oxo- or alpha-thioxophosphonate of formula (I). Out of the phosphonates of for...
The present invention provides a compound of the following formula (I): R3-NH-C(=X)-P(=O)OR1OR2 including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I, as well as geometrical isomers and optically active forms of the compounds of formula I and pharmaceutically accep...
La présente invention concerne des compositions utiles pour le traitement ou la surveillance d'états pathologiques associés à des protéinases renfermant du zinc, et tout particulièrement à des métalloprotéinases. L'ingrédient actif de ces compositions est un alpha-oxo- ou un alpha-thioxophosphonate re...
The present invention relates to a method of inhibiting tumor metastasis in an aminal by administering to an animal in need of such treatment an acrylaminoalkylpryridineamides represented by the formula ##STR1## wherein: R 1 and R 2 are the same or different members of the group consisting of halo, phenyl, substitute...
The present invention provides a compound of the following formula I: R 3 —NH—C(═X)—P(═O)OR 1 OR 2 including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I, as well as geometrical isomers and optically active forms of the compounds of formula I and phar...
本发明提供了下式(I)的化合物:R<sup>3</sup>-NH-C(=X)-P(=O)OR<sup>1</sup>OR<sup>2</sup>,其包括该式I化合物的药学上可接受的盐、溶剂化物、水合物和多晶型物,该式I化合物的几何异构体和旋光体,以及所述异构体和旋光体...
The invention provides a compound according to the formula: (see formula I) wherein R1 is a linear, saturated, mono-unsaturated, or poly-unsaturated, alkyl chain ranging in length from 2 to 30 carbon atoms; R2 is a linear, saturated, mono-unsaturated, or poly-unsaturated, alkyl chain ranging in length from 2 to 30 c...
The present invention relates to novel metalloproteinase inhibitors having an aryloxybenzenesulfonamide moiety and a carbamoylphosphonic acid moiety, to pharmaceutical compositions comprising them, and to their uses in the prevention and/or treatment of disease or disorder associated with MMP....
L'invention concerne des nouvelles méthodes de traitement de maladies, basées sur l'utilisation médicinale de lipides et de phospholipides liés de manière covalente à des monomères ou des polymères acceptables au plan physiologique. Des parties de phosphatidyléthanolamine conjuguées à des monomères ...
The present invention provides a compound of the following formula I: R 3 —NH—C(═X)—P(═O)OR 1 OR 2 including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I, as well as geometrical isomers and optically active forms of the compounds of formula I and pha...
The present invention relates to novel metalloproteinase inhibitors having an aryloxybenzenesulfonamide moiety and a carbamoylphosphonic acid moiety, to pharmaceutical compositions comprising them, and to their uses in the prevention and/or treatment of disease or disorder associated with MMP....
The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active ingredient in these compositions is an alpha-oxo- or alpha-thioxophosphonate of formula (I). Out of the phosphonates of for...
The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active ingredient in these compositions is an alpha-oxo- or alpha-thioxophosphonate of formula (I). Out of the phosphonates of for...
L'invention concerne des nouvelles méthodes de traitement de maladies, basées sur l'utilisation médicinale de lipides et de phospholipides liés de manière covalente à des monomères ou des polymères acceptables au plan physiologique. Des parties de phosphatidyléthanolamine conjuguées à des monomères ...
UN METODO PARA INHIBIR LA METASTASIS DE TUMORES EN UN ANIMAL POR MEDIO DE LA ADMINISTRACION DE UNA CANTIDAD EFICAZ DE UNA AMIDA HETEROCICLICA REPRESENTADA POR LA FORMULA EN DONDE R1 Y R2 SON LOS MISMOS O DIFERENTES MIEMBROS DEL GRUPO COMPUESTO POR HALO, FENIL, FENIL SUSTITUIDO Y UN GRUPO EN DONDE Q, R Y T SON INDEPENDI...
The present invention relates to a method of inhibiting tumor metastasis in an animal by administering to an animal in need of such treatment an acylaminoalkylpyridineamides represented by the formula wherein: R₁ and R₂ are the same or different members of the group consisting of halo, phenyl, subst...
PROBLEM TO BE SOLVED: To use lipid conjugates consisting of phospholipids as a pharmaceutical.SOLUTION: Phospholipid compounds (PL-Conjugates) of this invention have general formulae: [phosphatidyl ethanolamine-Y-]-X, [phosphatidyl serine-Y-]-X, [phosphatidyl choline-Y-]-X, [phosphatidyl inositol-Y-]-X, and [phosphatid...
The invention provides novel methods for treating disease based on the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers. Phosphatidylethanolamine moieties conjugated to physiologically acceptable monomers and polymers (PE conjugates) manifest an unexpectedly ...
The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active ingredient in these compositions is an alpha-oxo- or alpha-thioxophosphonate of formula (I). Out of the phosphonates of for...
The present invention provides a compound of the following formula (I): R3-NH-C(=X)-P(=O)OR1OR2including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I, as well as geometrical isomers and optically activeforms of the compounds of formula I and pharmaceutically accepta...
EL PRESENTE INVENTO SE REFIERE A UN METODO DE INHIBICION DE LA METASTASIS DE UN TUMOR EN UN ANIMAL MEDIANTE LA ADMINISTRACION DE UN TRATAMIENTO DE ACILAMINOALQUILPIRIDINEAMIDAS REPRESENTADO POR LA FORMULA EN DONDE: R1 Y R2 SON LOS MISMOS O DIFERENTES MIEMBROS DEL GRUPO COMPUESTO POR HALO, CENIL, CENIL SUSTITUIDO Y UN G...
PROBLEM TO BE SOLVED: To utilize a lipid conjugate configured with phospholipids as a medicine. SOLUTION: Phospholipid compounds (PL-conjugates) are described by general formula: [phosphatidylethanolamine-Y] n -X, [phosphatidylserine-Y] n -X, [phosphatidylcholine-Y] n -X, [phosphatidylinositol-Y] n -X, [phosphati...
The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active ingredient in these compositions is an alpha-oxo- or alpha-thixophosphpnate of formula (I). Out of the phosphonates of form...
A method of inhibiting tumor metastasis in an animal by administering to said animal a metastasis inhibiting effective amount of a heterocyclic amide represented by the formula: wherein: R₁ and R₂ are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ...
The present invention relates to novel metalloproteinase inhibitors having an aryloxybenzenesulfonamide moiety and a carbamoylphosphonic acid moiety, to pharmaceutical compositions comprising them, and to their uses in the prevention and/or treatment of disease or disorder associated with MMP....
A method of inhibiting tumor metastasis in an animal by administering to said animal a metastasis inhibiting effective amount of a heterocyclic amide represented by the formula: wherein: R₁ and R₂ are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ...
ABSTRACT A method of inhibiting tumor metastasis in an animal by administering to said animal a metastasis inhibiting effective amount of a heterocyclic amide represented by the formula: wherein: R1 and R2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ...
A phospholipid conjugate according to the general formula (I) or according to the general formula (II) for use in the treatment or prevention of a disorder selected from skin hypersensitivity, respiratory disease, eye disorder, and inflammatory bowel disease....
La présente invention porte sur de nouveaux inhibiteurs de métalloprotéinase comprenant une fraction aryloxybenzènesulfonamide et une fraction acide carbamoylphosphonique, sur des compositions pharmaceutiques les comprenant et sur leurs utilisations dans la prévention et/ou le traitement d'une maladie ou d'...
The present invention provides a compound of the following formula (I): R3-NH-C(=X)-P(=O)OR1OR2 including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I, as well as geometrical isomers and optically active forms of the compounds of formula I and pharmaceutically accep...
The invention provides novel methods for treating disease based upon the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers. Phosphatidylethanolamine moieties conjugated to physiologically acceptable monomers and polymers (PE conjugates) manifest an unexpectedl...
The present invention provides a compound of the following formula (I): R3-NH-C(=X)-P(=O)OR1OR2 including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I, as well as geometrical isomers and optically active forms of the compounds of formula I and pharmaceutically accep...
A method of inhibiting tumor metastasis in an animal without treating the tumor cells by administering to said animal a metastasis inhibiting effective amount of a heterocyclic amide represented by the formula: ##STR1## wherein: R 1 and R 2 are the same or different members of the group consisting of halo, phenyl, su...