BREUER ELI (Total 25 Patents Found)

Bisphosphonate compounds are of the Formula (I): ##STR1## wherein Y is ═O or ═N--OH and n is from 3 to 24, and further wherein when Y is ═O, (i) R 1 is hydrogen and R 2 is sodium, or (ii) R 1 is sodium and R 2 is methyl, and when Y is ═N--OH, R 1 is sodium and R 2 is methyl....
Novel bisphosphonates comprise compounds of the formula (I) ##STR1## wherein m and l are independently 1 or 2; R 1 represents hydrogen, a lower alkyl group, or an alkali metal cation; R 2 represents hydrogen, a lower alkyl group or an alkali metal cation; Y represents ═0 or ═N--OH, or --OH; and X represents --(CH...
L'invention concerne des composés bisphosphonates, leur préparation et des compositions pharmaceutiques contenant de tels composés en tant qu'ingrédients actifs. Ces compositions s'administrent généralement par voie orale et elles permettent de traiter efficacement les anomalies du métabolisme du cal...
The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active ingredient in these compositions is an alpha-oxo- or alpha-thioxophosphonate of formula (I). Out of the phosphonates of for...
The present invention provides a compound of the following formula (I): R3-NH-C(=X)-P(=O)OR1OR2 including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I, as well as geometrical isomers and optically active forms of the compounds of formula I and pharmaceutically accep...
La présente invention concerne des compositions utiles pour le traitement ou la surveillance d'états pathologiques associés à des protéinases renfermant du zinc, et tout particulièrement à des métalloprotéinases. L'ingrédient actif de ces compositions est un alpha-oxo- ou un alpha-thioxophosphonate re...
The present invention provides a compound of the following formula I: R 3 —NH—C(═X)—P(═O)OR 1 OR 2 including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I, as well as geometrical isomers and optically active forms of the compounds of formula I and phar...
本发明提供了下式(I)的化合物:R<sup>3</sup>-NH-C(=X)-P(=O)OR<sup>1</sup>OR<sup>2</sup>,其包括该式I化合物的药学上可接受的盐、溶剂化物、水合物和多晶型物,该式I化合物的几何异构体和旋光体,以及所述异构体和旋光体...
A method for treating patients having calcium related disorders includes using di- or tripeptide derivatives of bisphosphonates to enhance oral bioavailability of such compounds....
The present invention relates to novel metalloproteinase inhibitors having an aryloxybenzenesulfonamide moiety and a carbamoylphosphonic acid moiety, to pharmaceutical compositions comprising them, and to their uses in the prevention and/or treatment of disease or disorder associated with MMP....
The present invention provides a compound of the following formula I: R 3 —NH—C(═X)—P(═O)OR 1 OR 2 including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I, as well as geometrical isomers and optically active forms of the compounds of formula I and pha...
The present invention relates to novel metalloproteinase inhibitors having an aryloxybenzenesulfonamide moiety and a carbamoylphosphonic acid moiety, to pharmaceutical compositions comprising them, and to their uses in the prevention and/or treatment of disease or disorder associated with MMP....
The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active ingredient in these compositions is an alpha-oxo- or alpha-thioxophosphonate of formula (I). Out of the phosphonates of for...
The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active ingredient in these compositions is an alpha-oxo- or alpha-thioxophosphonate of formula (I). Out of the phosphonates of for...
Novel bisphosphonates comprise compounds of the formula (I) ##STR1## wherein m and l are independently 1 or 2; R 1 represents hydrogen, a lower alkyl group, or an alkali metal cation; R 2 represents hydrogen, a lower alkyl group or an alkali metal cation; Y represents ═0 or ═N--OH, or --OH and X represents --(CH ...
The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active ingredient in these compositions is an alpha-oxo- or alpha-thioxophosphonate of formula (I). Out of the phosphonates of for...
The present invention provides a compound of the following formula (I): R3-NH-C(=X)-P(=O)OR1OR2including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I, as well as geometrical isomers and optically activeforms of the compounds of formula I and pharmaceutically accepta...
The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active ingredient in these compositions is an alpha-oxo- or alpha-thixophosphpnate of formula (I). Out of the phosphonates of form...
The present invention relates to novel metalloproteinase inhibitors having an aryloxybenzenesulfonamide moiety and a carbamoylphosphonic acid moiety, to pharmaceutical compositions comprising them, and to their uses in the prevention and/or treatment of disease or disorder associated with MMP....
L'invention porte sur de nouveaux dérivés de certains phosphonates et bisphosphonates et spécialement sur des composés du type pamidronate ou alendronate et plus particulièrement sur les dérivés amonoacyle et peptidyle desdits composés. L'invention porte en outre sur des préparations pharmaceutiques co...
La présente invention porte sur de nouveaux inhibiteurs de métalloprotéinase comprenant une fraction aryloxybenzènesulfonamide et une fraction acide carbamoylphosphonique, sur des compositions pharmaceutiques les comprenant et sur leurs utilisations dans la prévention et/ou le traitement d'une maladie ou d'...
The present invention provides a compound of the following formula (I): R3-NH-C(=X)-P(=O)OR1OR2 including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I, as well as geometrical isomers and optically active forms of the compounds of formula I and pharmaceutically accep...
The present invention provides a compound of the following formula (I): R3-NH-C(=X)-P(=O)OR1OR2 including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I, as well as geometrical isomers and optically active forms of the compounds of formula I and pharmaceutically accep...